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WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
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Lipoprotein Immune Complexes As Markers of Atherosclerosis
Orekhov A.N., Kalenich O.S., Tertov V.V., Novikov I.D.
USSR Cardiology Research Centre, Moscow, Russia.
Inter. Journal of Tissue Reactions 1991, Vol. XIII, No.
5, pp. 233-236
323 KA |
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Summary
Recently we have demonstrated that cholesterol level in LDL-containing
circulating immune complexes (CIC cholesterol) correlates with
the presence of coronary atherosclerosis. In the present study
we attempted to clarify whether CIC cholesterol level correlates
with the severity of coronary atherosclerosis.
The second task was to reveal the diagnostic value of CIC
cholesterol in comparison with other lipid and lipoprotein parameters
used as markers of dislipidaemia associated with atherosclerosis.
The subjects were 107 patients with angiographically-documented
coronary atherosclerosis and 66 patients with documented extracoronary
atherosclerosis. Only CIC cholesterol and the apo B/apo A-1 ratio
contributed strongly to the discrimination between patients with
coronary atherosclerosis and those without stenoses. On the other
hand, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol,
apo B, Lp(a) and apo A1 did not correlate with the presence and
severity of coronary atherosclerosis. Subjects with stenosis of
extracoronary arteries had significantly higher CIC levels than
healthy donors. Sensitivity, specificity and accuracy of coronary
atherosclerosis diagnosis were assessed for each parameter examined.
It was revealed that CIC cholesterol is the most reliable marker
of coronary atherosclerosis as compared to other chemical parameters.
In addition, the CIC cholesterol level diagnoses extracoronary
atherosclerosis with high accuracy. |
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