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WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
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Proteinase
administration reduces growth of human breast and pancreatic
cancer in nude mice and diminishes expression of some tumorigenesis
biomarkers
Wald M.,1 Šebková V.,2 Österreicher
J.,3 Zadinová M.,4 Pou?ková P.4
1 Department of Surgery, Second Medical School, Charles
University, Prague, Czech Republic
2 Department of Immunology, St. Elisabeth Hospital, Na
Slupi 6, Prague, Czech Republic
3 Purkyn? Military Medical Academy, Hradec Králové,
Czech Republic
4 Department of Biophysics, First Medical Schoo, Charles
University, Prague, Czech Republic
Int. J. Immunotherapy 2001, Vol. XVII, No. 2/3/4, pp.
65-73 - ISSN 0255-9625
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Summary
The aim of this investigation was to study the effect
of proteinases on the growth of human breast and pancreatic
cancer transplanted to nude mice. Animals were divided
into active groups receiving a specific mixture of serine
and cysteine proteinases, and control groups receiving
saline. Enzyme treatment significantly reduced tumor growth
(up to 50 %) irrespective of the transplanted cell line.
To study the effect of proteolytic enzymes on several molecular
biomarkers that may play a role in breast cancer tumorigenesis,
expression of Ki-67, c-erbB-2, bcl-2, and CD-34 was investigated
using immunohistochemical examination. Expression of Ki-67
and c-erbB-2 was significantly reduced in the enzyme-treated
animals compared with control animals. Evaluation of necroses
revealed that the extent of necrotic tissue in the enzyme-treated
mice was approximately 30% lower than in the control
group. In the enzyme group, reduced density of CD44 adhesion
molecule was measured on the surface of tumor cells.
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© Copyright 2004 WAM Essentials,
Inc. All Rights Reserved.
None of the material contained herein may be reproduced without
the prior written consent of WAM Essentials, Inc. |
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