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WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
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Interaction
Between Proteases and Blood-Brain Barrier: Possible Sequellae
for Clinical Praxis
Š?astny F.1,2,3, Pliss L.3,4, Höschl C.1,2,3
1Psychiatrické centrum Praha
23. léka?ská fakulta Univerzity Karlovy
3Centrum neuropsychiatrických studií, Praha
4Department of Biochemistry, School of Medicine and Biomedical
Sciences,
State University of New York at Buffalo, USA
Psychiatrie 2002, Vol. 6, No. 4, pp. 230–241
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Summary
Review introduces newer findings on the mode of action
of proteases mostly used in clinical treatment. Systemic
anti-inflammatory, anti-swelling, and anti-allergic effects
(including the brain) can be supposed only if relevant
proteases cross enteric and blood-brain barriers after
oral administration, reach the system in detectable amount,
and do not loose their enzymatic activity. Authors summarize
findings supporting such a possibility, and point to limitations
and further perspectives of the clinical use of proteolytic
enzymes.
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